An experimental HIV vaccine has worked and defended primates
For a very long time, scientists from around the world are trying to find a way to defeat the insidious HIV, which claimed many lives already. The group of experts from of the research center of Scripps Research (USA) the last 20 years developed a vaccine against a dangerous virus, and an experimental drug recently passed the first test and showed high efficiency in the use of primates, protect animals from infection.
As reported in the journal Immunity, the authors used the following approach: the immune system needs to be "taught" to work with the virus and produce antibodies that are "beaten" to HIV in vulnerable point. In fact, it sounds simple, but in reality it is a real problem. To achieve the result, scientists working on the immune system viral envelope protein having the structure trimmer. But for a long time, experts could not ensure that the protein was stable and have been successful a few years ago.
Next, on the basis of a stable protein structure of the vaccine it has been established that tested non-human primate genus macaques. Scientists have three groups of animals: 6 low titer neutralizing antibodies, 6 - high and 12 did not receive the vaccine and acted as the control group. After that, the animals were a special version of HIV that can infect animals, which contains the same protein structure, based on which the vaccine was developed. This same protein is included in the composition of the human HIV variant. It turned out that the vaccine worked on animals initially had high titer neutralizing antibodies. Other primates infected with the virus. Scientists have realized that it is stimulated by neutralizing antibodies of the immune system have been able to protect animals against the virus. This is fundamentally different from that of other studies that aim at improving the T cells of the immune system.
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