Confirmed: a molecular "switch" destroy cancer cells without complications
our body cells regularly die and are replaced by new ones. The mechanism of "planned" cell death is called apoptosis and is quite normal physiological process. But what is typical for normal cells, absent in cancer cells. They simply lost this function. But what if you could make cancer cells "remember" this mechanism? US researchers say it's possible. They even confirmed this in a series of experiments.
According to new research, micro-RNA can be used to send cancer cells to "reports of self-destruction, which they can not ignore." We wrote that earlier this year, researchers from Northwestern University (located in the suburbs of Chicago, in Evanston) described the mechanism by which every cell in the body can be programmed for destruction. Now the same research group reported that they were able to finally crack the "code" required to run this sequence, or even confirm these data in the course of experiments.
As reported by the authors of the work in a new study indicate cell death sends a ribonucleic acid (RNA) and the specific microRNAs. A code itself consists of six nucleotide small interfering RNA (siRNA). Contact with all six of these nucleotides causes irreversible changes in the cell are similar to those that occur when exposed to chemotherapeutic drugs. During laboratory tests it was found out on the tumor cells that the code at the same time destroying several genes required for cell survival, so cancer is not able to develop a resistance. In addition, this approach is almost not affect healthy tissue, and therefore the number of complications is minimal.
"Now that we know," the murder of the code, "we can start the mechanism, without the need for chemotherapy. We can use these microRNAs directly enter them into the cells and run "switch" that causes destruction of the tumors. "- said the lead author, Professor Peter Marcus.
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