How to make effective drugs against influenza?
One of the main problems of the effective action of drugs is that while they "travel" through the body of the substances just destroyed our defense system. In addition, drugs are often toxic and cause no little harm. It has long been targeted are being developed (ie directly in the place of defeat) drug delivery. But what if the disease is spread throughout the body, as is the case in viral diseases? Solution found Russian scientists.
For the development of responsible specialists from the Tomsk Polytechnic University, First Pavlov State Medical University of St. Peterburg, in collaboration with the School of Engineering and Materials Science, University of London Queen Mary (United Kingdom) and the Influenza Research Institute of Ministry of Health of Russia. Joint invention is microcontainers for medicinal substances. With this method, almost no effect disintegration of therapeutic substances, and the action of the drug becomes much more effective, which can significantly reduce the incidence of seasonal.
In this case, the drug has a very usable form: it is sprayed into the nasal cavity in the form of a spray and then the microcapsules are distributed to the nasopharynx and enter the lungs. According to scientists, the usual active substances in the human body is not more than an hour, after which they are destroyed. Microcapsules gradually release the drug so that the drug is active during the day. As told in an interview to RIA Novosti Junior Researcher, Laboratory of new dosage forms RASA Center at the National Research Tomsk Polytechnic University Alexander thymine,
"Sami containers consist of polysaccharides and polypeptides. This biodegradable polymers, which are absolutely not harm the body.
In microcontainers placed small interfering RNAs that can inhibit influenza virus H1N1. Due to the extremely high capacity of microcapsules provided off activity of influenza virus genes by means of RNA interference and thus achieves a reduction in viral load. "
Who conducted preclinical studies in animal technology. Thanks to the new universal platform may be the creation of a complex of the drug, has antiviral activity against several strains of influenza and other respiratory viruses even.