Cultured ovaries were successfully implanted with the sterilized mice
The technology of creating artificial organs in recent years quite well advanced, and it gives hope that it will be possible to replace a person of any body in the future. For example, we recently wrote about the creation of an artificial uterus. Now experts from Chicago were able to grow and successfully transplanted into rodents artificial ovary.
The ovaries were printed on special designs using the 3D-bioprinter. Later designs were inhabited by cell culture. The experiment was conducted on the basis of Feinberg School of Medicine, led the research and Dr. Teresa Woodruff. The biggest challenge in the manufacture of artificial ovary turned out to provide a multilayer porous structure that supports immature follicles and surrounding the hormone-producing cells. During the study, a team of experts to find out what the follicles framework ensures functioning and survival of germ cells. It was further printed multiple mesh layers and formed on the basis of their scaffold for artificial ovary to 2 millimeters thick. Inside the frame was placed from 40 to 50 immature follicles of mice. These artificial ovary were implanted into the body of seven mice. All rodents managed to produce healthy offspring.
"We need to do a lot of work, but a demonstration of the fact that we created 3D-functioning ovaries - this is a big breakthrough. It is very important that we have shown that it is feasible. It is possible that in the case of successful completion of a series of experiments in a similar way it will be possible to restore the reproductive function of patients who had undergone removal of the ovaries due to diseases or after chemotherapy. "