With the help of genetic engineering managed to eliminate HIV in animals
The fight against incurable diseases are probably one of the first places in the world medical practice. According to official statistics, more than 35 million people on our planet live with dangerous diseases of human immunodeficiency virus (HIV). Despite significant advances in the maintenance treatment of patients with HIV medication has not yet been created. But, perhaps, scientists from the School of Medicine Lewis Katz managed to get closer to its creation. According to the publication Science Direct, with reference to the journal Molecular Therapy, experts managed to completely destroy a dangerous virus in cells of infected animals.
For the development meet Dr. Kamel Khalili, about the work that we have already mentioned. Dr. Kamel help his colleagues - Hu Wenhui Laura Carnell and Won Bin Jung. To make a breakthrough, scientists were able, thanks to technology editing of the genome, it is widely known as CRISPR / Cas9. For their work the experts used several groups of mice, including genetically modified rodents were present in the blood of which were human immune cells. These mice were infected with HIV-1. As Dr. Hu commented,
"We have confirmed the data from our previous work and demonstrated that it is extremely effective. For the new research, we used several groups of animals: one was a carrier of the acute form of the disease, the other - chronic. "
The specialists were able to deactivate the virus HIV-1 and 65-95% reduced expression of viral RNA. In the case of the use of CRISPR / Cas9 on infected rodents method proved to be effective in 96% of cases. In the course of only one stage of the viral gene editing segments have been completely removed from human cells. Scientists have managed to overcome the virus in the spleen, lungs, heart, intestines and the brain of mice. As the study authors say, the next stage of their trials are experiments on primates, well, the ultimate goal of the experiment - the beginning of full-fledged clinical trials on humans and the creation of active drugs.